个人介绍

      丁小雷，william hill 威廉希尔特聘教授，入选上海市海外高层次人才项目；主要研究皮肤的发生、发育、稳态及衰老的过程与机理，探讨组织再生修复的分子调控机制及其在病理情况下的变化，开发新材料、新药物来改进皮肤的功能与修复过程；主持国家自然科学基金面上项目，上海市创新人才项目。代表性论文发表在：Cell Metabolism, Nature Communications, Cancer Research, Journal of Allergy and Clinical Immunology, Journal of Dermatology Investigation 等国际期刊；于2017年获得欧洲皮肤学会青年研究奖（Egon-Macher Awards）；2020年获得La Roche-Posay ROSA皮肤科学研究奖。

代表性论文

1. Wang J, Ding X. IL-17 signaling in skin repair: safeguarding metabolic adaptation of wound epithelial cells. Signal Transduction and Targeted Therapy. 2022 Oct 8;7(1):359.

2. Wang J, Cui B, Chen, Z, Ding X. The regulation of skin homeostasis, repair and the pathogenesis of skin diseases by spatiotemporal activation of epidermal mTOR signaling. Frontiers in Cell and Developmental Biology. 2022 Jul 22;10:950973.

3. Willenborg S, Sanin DE, Jais A, Ding X, Ulas T, Nüchel J, Popović M, MacVicar T, Langer T, Schultze JL, Gerbaulet A, Roers A, Pearce EJ, Brüning JC, Trifunovic A, Eming SA. Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metabolism. 2021 Dec 7;33(12):2398-2414.

4. Ding X, Kakanj P, Leptin M, Eming SA. Regulation of the Wound Healing Response during Aging. Journal of Investigative Dermatology. 2021 Feb 5:S0022-202X(20)32360-5.

5. Kim SC*, Ding X*, Allmeroth K, Biggs LC, Kolenc OI, L'Hoest N, Chacón-Martínez CA, Edlich-Muth C, Giavalisco P, Quinn KP, Denzel MS, Eming SA, Wickström SA. Glutamine metabolism controls stem cell fate reversibility and long-Term maintenance in the hair follicle. Cell Metabolism. 2020 Oct 6;32(4):629-642 (*equal contribution).

6. Knipper J, Ding X, Eming, S. Diabetes impedes the epigenetic switch of macrophages into repair mode. Immunity. 2019 Aug 20;51(2):199-201.

7. Ding X, Willenborg S, Bloch W, Wickstrom S, Wagle P, Brodesser S, Rosers A, Jais A, Brüning J, Hall M, Rüegg M, Eming SA. Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. Journal of Allergy and Clinical Immunology. 2020 145(1):283‐300.

8. Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA. 2016. mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Communications 7:13226.

9. Ding X*, Lucas T*, Marcuzzi GP, Pfister H, Eming SA. 2015. Distinct functions of epidermal and myeloid-derived VEGF-A in skin tumorigenesis mediated by HPV8. Cancer Research 75: 330-343 (*equal contribution).